Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 7503생성일: 2026년 10월 24일
Isopropanol → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride
https://huagongshe.com/ko/reaction/7503
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| 반응물 | 4-Chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride | HCID 21991058 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 2-Pentanol | HCID 22386 | — |
| 생성물 | 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride | HCID 21991016 | 106.3% |
반응 단계
A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (150 mg, 0.36 mmol), (prepared as described for the starting material in Example 12), 4-chloro-2-fluoroaniline (77 mg, 0.53 mmol) in 2-pentanol (4 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 1 hour. The mixture was allowed to cool and isopropanol was added. The resulting precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (185 mg, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07087602B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-0b7086452ac64a56a87f5db7ea740a99 |
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| 출처 메모 | uspto-grants-2006_08 |
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