Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide | HCID 68825664 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester | HCID 68822191 | — |
반응 단계
In analogy to the procedure described for example 1 b], 2-(1H-indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide was reacted with bromo-acetic acid ethyl ester in the presence of cesium carbonate and potassium iodide in acetonitrile under reflux conditions to give the title compound as off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07405236B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-64f3c470e8ab46bf901b8c4e2407e75c |
| 출처 메모 | uspto-grants-2008_07 |