참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trimethylsilyl cyanide | HCID 82115 | — |
| 반응물 | 6-Bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine 4-oxide | HCID 86707962 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 6-Bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile | HCID 86707963 | 76% |
반응 단계
To a stirred mixture of 6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine 4-oxide (3.8 g 14 mmol), Et3N (19.51 mL, 140 mmol) and DCE (20 mL) was added trimethylsilyl cyanide (9.38 mL, 70.0 mmol). The reaction mixture was stirred at 80° C. for 5 h, subsequently concentrated in vacuo, and purified by silica gel chromatography eluting with EtOAc/DCM (1:1) to give the title compound as an off-white solid (2.50 g, 76%, 2 steps). ESI-MS m/z [M+H]+ calc'd for C9H6BrN3, 236, 238; found 236, 238.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835420B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-5bf51d1d43ca44e6be25d8924d2e8dd3 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
