Methyl valinate hydrochloride → (S)-2-({3-[4-(3-cyclohexyl-ureido)-phenyl]-isoxazole-5-carbonyl}-amino)-3-methyl-butyric acid methyl ester

참여 물질

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The title compound was prepared from 3-[4-(3-cyclohexyl-ureido)-phenyl]-isoxazole-5-carboxylic acid and (S)-2-amino-3-methyl-butyric acid methyl ester hydrochloride as set forth in Example 5 and was obtained in 68% yield. Mass (ES+): 443 (M++1); IR (KBr): 3382, 3345, 3290, 2932, 1746, 1665, 1652, 1543; 1H NMR (DMSO-d6) δ: 0.91 (2×d, 6H), 1.08-1.78 (4×m, 10H), 2.16 (m, 1H), 3.42 (br, 1H), 3.53 (s, 3H), 4.26 (t, 1H), 6.14 (d, 1H), 7.48 (d, 2H), 7.60 (s, 1H), 7.72 (d, 2H), 8.56 (s, 1H), 9.12 (d, 1H).

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