Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → (R)-N-(benzoyl)-3-methyl-N'-[2-(5-methoxy-benzothiazol-2-yl)-2-imino-1-cyano-ethyl]-piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 반응물 | 5-Methoxy-1,3-benzothiazole-2-carbonitrile | HCID 15274072 | — |
| 반응물 | (R)-N-benzyl-3-methyl-N'-cyanomethylpiperazine | HCID 86601950 | — |
| 생성물 | (R)-N-(benzoyl)-3-methyl-N'-[2-(5-methoxy-benzothiazol-2-yl)-2-imino-1-cyano-ethyl]-piperazine | HCID 86601949 | — |
반응 단계
NaHMDS (0.77 ml, 1M in THF) was added into a solution of (R)-N-benzyl-3-methyl-N′-cyanomethylpiperazine (100 mg) and 2-cyano-5-methoxy-benzothiazole (58 mg) in THF (10 ml). The reaction was stirred for 10 hours. Then 4 ml of the reaction mixture was separated and quenched with MeOH. After solvents were removed under vaccum, the residue was purified using Shimadzu automated preparative HPLC System to give (R)-N-(benzoyl)-3-methyl-N′-[2-(5-methoxy-benzothiazol-2-yl)-2-imino-1-cyano-ethyl]-piperazine (1.3 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087610B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-28046646c1654096b7755cc2c17642b7 |
| 출처 메모 | uspto-grants-2006_08 |