Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Pyrrolidone → 1-(4-Iodobenzyl)pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Pyrrolidone | HCID 12025 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Iodobenzyl bromide | HCID 954258 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(4-Iodobenzyl)pyrrolidin-2-one | HCID 50992862 | — |
반응 단계
To 140 μl (1.68 mmol) 2-pyrrolidone in 5 mL DMF are added 110 mg (2.53 mmol) sodium hydride. Then 500 mg (1.68 mmol) 4-iodobenzyl bromide are added by several portions and the resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is resolved in DCM and water. The layers are separated and the organic layer is dried with Na2SO4, filtrated and the solvent is removed in vacuo. The crude product is purified by HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835472B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-392c23370f18485ea0366c42b5d658a8 |
| 출처 메모 | uspto-grants-2014_09 |