Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → HCID 178490701, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | HCID 178490700 | HCID 178490700 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 178490701 | HCID 178490701 | 100.6% |
반응 단계
The product from Example 21A (50 mg, 0.14 mmol) in THF (10 mL) was treated with sodium borohydride (21 mg, 0.57 mmol) at −40° C. for 1 hr, quenched with saturated NH4Cl, extracted with EtOAc (2×), dried over MgSO4, filtered and concentrated to afford 50 mg of the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 1.67 (s, 9 H) 3.93 (s, 3 H) 4.88 (s, 2 H) 6.94 (d, J=8.85 Hz, 1 H) 7.37 (dd, J=8.85, 3.05 Hz, 1 H) 8.05 (s, 1 H) 8.08 (d, J=2.75 Hz, 1 H); MS (DCI/NH4+) m/z 355 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835475B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-ffa7ef6890664982851b7101d2965c18 |
| 출처 메모 | uspto-grants-2014_09 |