참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Iodobenzene-1-sulfonyl chloride | HCID 627400 | — |
| 반응물 | 1-Bromo-9H-carbazole | HCID 11230335 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 9-(Benzenesulfonyl)-1-bromocarbazole | HCID 67405182 | — |
반응 단계
19.6 g (80 mmol) of 1-bromocarbazole are initially introduced in 1000 ml of THF, and 8.9 g (223.3 mmol) of NaH (60% in oil) are added at 0° C. 24 g (80 mmol) of 2-iodobenzenesulfonyl chloride are subsequently added to the mixture, which is then stirred at 40° C. for 12 h. The organic phase is dried over MgSO4, and the solvent is removed in vacuo. The residue is recrystallised from acetone and finally sublimed in a high vacuum. Yield: 29 g (574 mmol), 72% of theory, purity according to HPLC 99.9%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08835626B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-3c43d7a676ae43afb3bbd4062c96f588 |
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| 출처 메모 | uspto-grants-2014_09 |
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