Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-6-methylpyridine → 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-6-methylpyridine | HCID 15765 | — |
| 반응물 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 생성물 | 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine | HCID 22060543 | — |
반응 단계
In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 2-amino-6-methylpyridine gave 2-chloro-5-fluoro-N4-(6-methylpyridin-2-yl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.23 (s, 1H), 8.19 (s, 1H), 8.12 (d, 1H, J=3 Hz), 7.55 (bs, 1H), 7.69 (t, 1H, J=7.4 Hz), 9.35 (d, 1H, J=7.5 Hz); 19F NMR (CDCl3): −44073; LCMS: purity: 96%; MS (m/e): 239 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835430B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-214193e36dc4410780852da34b52210c |
| 출처 메모 | uspto-grants-2014_09 |