Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → N-((S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxy-pyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Bromomethylcyclopropane | HCID 81503 | — |
| 반응물 | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| 반응물 | (2S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 22831536 | — |
| 생성물 | N-((S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxy-pyridine-2-carboxamide | HCID 66663511 | — |
반응 단계
According to method G, (S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-ylamine was coupled with 5-hydroxypyridine-2-carboxylic acid and the product was then alkylated on the phenolic hydroxyl function with bromomethylcyclopropane according to method a Finally, the amide function was alkylated according to method B with methyl iodide. The product was thus obtained with the molecular weight of 415.33 (C21H23BrN2O2); MS (ESI): 415 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841290B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-88d81b669a224bbfa615843c2afeea02 |
| 출처 메모 | uspto-grants-2014_09 |