Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Chloromethyl)-5-methylpyridine → 3-(3-(4-(5-Methyl-pyridin-2-ylmethoxy)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Chloromethyl)-5-methylpyridine | HCID 588056 | — |
| 반응물 | 4-(5-(2-Amino-pyridin-3-yl)isoxazol-3-ylmethyl)phenol | HCID 25114386 | — |
| 생성물 | 3-(3-(4-(5-Methyl-pyridin-2-ylmethoxy)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine | HCID 59255075 | 33% |
반응 단계
4-(5-(2-Amino-pyridin-3-yl)isoxazol-3-ylmethyl)-phenol (50 mg, 0.19 mmol) described in Manufacturing Example 5-1-1 and the 2-chloromethyl-5-methyl-pyridine (32 mg, 0.23 mmol) described in Manufacturing Example 42-1-2 were used to obtain the title compound (23 mg, 33%) according to the methods similar to those of Example 10.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841327B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-416a143b10ac40caa4ee4d9b7ef032ef |
| 출처 메모 | uspto-grants-2014_09 |