Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-3-(trifluoromethyl)aniline → Ethyl 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| 반응물 | Ethyl 4-isocyanatobenzoate | HCID 589805 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)benzoate | HCID 2212218 | 97% |
반응 단계
To a solution of ethyl 4-isocyanatobenzoate (3.14 g, 16.4 mmol) in CH2Cl2 (30 mL) was added 4-chloro-3-(trifluoromethyl)aniline (3.21 g, 16.4 mmol), and the solution was stirred at room temp. overnight. The resulting slurry was diluted with CH2Cl2 (50 mL) and filtered to afford N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-ethoxycarbonylphenyl)urea as a white solid (5.93 g, 97%): TLC (40% EtOAc/60% hexane) Rf 0.44.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841330B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-99b39eae20d145379a672358c08bdaf8 |
| 출처 메모 | uspto-grants-2014_09 |