Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofurfurylamine → 3-(4-Nitrophenoxy)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofurfurylamine | HCID 253298 | — |
| 반응물 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 생성물 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 생성물 | 3-(4-nitrophenoxy)-N-(tetrahydro-2-furanylmethyl)benzamide | HCID 2986507 | — |
반응 단계
Entry 63: 4-(3-Carboxyphenoxy)-1-nitrobenzene was synthesized according to Method A13, Step 2. 4-(3-Carboxyphenoxy)-1-nitrobenzene was coupled with tetrahydrofurfurylamine according to Method A13, Step 3 to give 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene. According to Method A13 Step 4, 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-(N-(tetrahydrofurylmethyl)carbamoyl)phenoxy)aniline to afford the urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841330B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-960654546b55426a858bdc82374e4060 |
| 출처 메모 | uspto-grants-2014_09 |