참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(2-Bromoethyl)-1,3-dioxolane | HCID 87776 | — |
| 반응물 | 2-Amino-5-methylthiazole | HCID 351770 | — |
| 생성물 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | 3-(2-(1,3-dioxolan-2-yl)ethyl)-5-methylthiazol-2(3H)-imine | HCID 68622400 | — |
반응 단계
A mixture of 2-amino-5-methylthiazole (1.0 g, 8.7 mmol) and 2-(2-bromoethyl)-1,3-dioxolane (1.1 mL, 8.7 mmol) was warmed to 85° C. and was allowed to stir for 18 hours. The mixture was cooled to ambient temperature and purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 215 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08841334B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-5c53d03dd8614952b188228f43961fdb |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
