Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenol → Phenyl 2-hydroxy-4,5-dimethoxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-Hydroxy-4,5-dimethoxybenzoic acid | HCID 11564650 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | Phenyl 2-hydroxy-4,5-dimethoxybenzoate | HCID 53424183 | 64% |
반응 단계
In 10 g of xylene were suspended 1.0 g of compound (2a) and 522 mg of phenol, to which 460 μL of SOCl2 was then added dropwise before heating to reflux for 3 hours, followed by further adding 184 μL of SOCl2 and additionally heating to reflux for one hour. The reaction solvent was distilled off, followed by adding methanol to the residue before stirring. The precipitated crystal was collected by filtration to provide 880 mg of phenyl 2-hydroxy-4,5-dimethoxybenzoate (3a) at a yield of 64%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841461B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-2bea1a01e4cd41318cabd7c3284d6b40 |
| 출처 메모 | uspto-grants-2014_09 |