Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-4-iodoaniline → 5-[(2-Fluoro-4-iodophenyl)amino]-2-methylisonicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-4-iodoaniline | HCID 185694 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | 5-Fluoro-2-methylisonicotinic acid | HCID 57649620 | — |
| 생성물 | 5-[(2-Fluoro-4-iodophenyl)amino]-2-methylisonicotinic acid | HCID 11501608 | — |
반응 단계
5-[(2-fluoro-4-iodophenyl)amino]-2-methylisonicotinic acid was synthesized according to the general procedure of Method 1 as, outlined above, starting with 200 mg (1.29 mmol) of 5-fluoro-2-methylisonicotinic acid, 370 mg (1.55 mmol) of 2-fluoro-4-iodoaniline and two portions of lithium bis(trimethylsilyl)amide (3.35 ml, 3.35 mmol), and (1.55 ml, 1.55 mmol). Yield: 30 mg, 6%, LC/MS [5.5 min; 473 (M+1)]
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841459B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-126a8666d0394fa3a3dc48af8ad2df31 |
| 출처 메모 | uspto-grants-2014_09 |