Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-fluoro-benzyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-fluoro-benzyl)-amine | HCID 66631535 | 82% |
반응 단계
Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.21 g, 0.79 mmol) was reacted with 4-fluorobenzaldehyde (0.098 g, 0.79 mmol) in the presence of glacial acetic acid (0.047 g, 0.79 mmol) in 1,2-dichloroethane (20 ml), and then reduced by NaCNBH3 (0.059 g, 0.95 mmol) in methanol (5 ml) (Procedure D) to give compound 16b (0.24 g, 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-2adb5b9776164c7b867a501b16b6608e |
| 출처 메모 | uspto-grants-2014_09 |