참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclopropanemethanamine | HCID 75646 | — |
| 반응물 | 2-Amino-4-chloropyrimidine | HCID 223332 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N4-(cyclopropylmethyl)pyrimidine-2,4-diamine | HCID 20277654 | — |
반응 단계
To cyclopropylmethanamine (3.62 g, 50.9 mmol) in ethanol (90 mL) was added solid 4-chloropyrimidin-2-amine (6.00 g, 46.3 mmol). The reaction was stirred at reflux (100° C. oil bath) for 16 h. The reaction was cooled to room temperature and solvent was removed in vacuo. The product 237 obtained in quantitative yield. LCMS-ESI (POS), M/Z, M+1: Found 165.0, Calculated 165.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08841312B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-26b22e2f8cc54faebcb8ade065724197 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
