Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → (R)-t-Butyl 2-((t-butyldimethylsilyloxy)methyl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | (R)-2-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 24820219 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (R)-t-Butyl 2-((t-butyldimethylsilyloxy)methyl)piperazine-1-carboxylate | HCID 58299667 | 60.3% |
반응 단계
(R)-t-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate (1.15 g, 5.32 mmol), t-butylchlorodimethylsilane (0.882 g, 5.85 mmol), and imidazole (0.796 g, 11.7 mmol) were stirred in dichloromethane (3 mL) for three days. The solution was added to aqueous K2CO3 (30 mL) and extracted with dichloromethane (3×30 mL). The combined organics were dried (MgSO4) and evaporated to give a yellow oil. Silica gel chromatography (gradient elution hexanes/0-50% ethyl acetate) afforded compound 308 as a colorless oil (1.06 g, 60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841312B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-57b2c2a245a64c9493a362b4fa19c332 |
| 출처 메모 | uspto-grants-2014_09 |