Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole → 3-ethyl-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole | HCID 67259703 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-ethyl-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine | HCID 67259804 | 97.5% |
반응 단계
A mixture of 1-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole (161 mg, 0.547 mmol) and 20% palladium hydroxide on carbon (38.4 mg, 0.0547 mmol) was stirred in methanol (3 mL) under an atmosphere of hydrogen for 3 hours. The mixture was diluted with methanol and filtered through glass fiber filter paper. The filtrate was concentrated under reduced pressure to give 3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine (142 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841455B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b4bb128a1d1f45988ab712307097ce50 |
| 출처 메모 | uspto-grants-2014_09 |