Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 79992생성일: 2026년 10월 24일
Ammonia acetate → 2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/ko/reaction/79992
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia acetate | HCID 12432 | — |
| 반응물 | 2-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 66621386 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 66620559 | 35.5% |
반응 단계
A mixture of 2-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester (1.05 g, 2.4 mmol) and ammonia acetate (3.7 g, 20 eq.) in Xylene (2 mL) was heated in microwave at 110° C. for 2 hours. The mixture was concentrated and purified by flash column chromatography (silica gel, 20 to 80% ethyl acetate/hexane) to give 2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester (356 mg, containing 15% starting material, yield 35%). LCMS-ESI−: calc'd for C19H21BrN4O2: 417.30. Found: 418.9 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08841278B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-e61d547aa18f4aab85bb5b401fa443f6 |
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| 출처 메모 | uspto-grants-2014_09 |
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