Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1-(2-Chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 반응물 | 3-Amino-4-picoline | HCID 137935 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-(2-Chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea | HCID 14834325 | 86.1% |
반응 단계
1-Chloro-2-isocyanato-ethane (5.91 ml, 69.35 mmol) was added dropwise to a stirred solution of 4-methyl-pyridin-3-ylamine (5 g, 46.23 mmol) in toluene (180 mL) at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 8.5 g (86% yield) of 1-(2-chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045173E1 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-30b9272dcda744cebc823dc473c6935a |
| 출처 메모 | uspto-grants-2014_09 |