Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 3-Chloro-2,2-dimethyl-propionyl azide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 3-Chloro-2,2-dimethylpropanoyl chloride | HCID 61345 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Hexane | HCID 8058 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-Chloro-2,2-dimethyl-propionyl azide | HCID 59636160 | 61.4% |
반응 단계
Sodium azide (4.64 g, 71.38 mmol) was added to a solution of 3-chloro-2,2-dimethyl-propionyl chloride (I-200a: 6 g, 35.71 mmol) in 1,4-dioxane (15 mL) and water (15 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (5% ethylacetate in hexane). The reaction mixture was extracted with diethyl ether and the organic layer was dried over Na2SO4 to afford 3.5 g of the product (61.40% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045173E1 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-61aeecbee34f43d2baa40b2c427cbaf5 |
| 출처 메모 | uspto-grants-2014_09 |