Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Bromomethyl)-1,2-difluorobenzene → 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| 반응물 | 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991432 | — |
| 반응물 | 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one | HCID 21991662 | — |
| 생성물 | 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991666 | 92.1% |
반응 단계
Following the procedure of Example 1 (6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3,4-difluorobenzyl bromide were reacted to yield the title compound as a yellow crystalline powder (yield: 92.1%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087606B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-7fbe98d2d8c545b9967357d14a5f9904 |
| 출처 메모 | uspto-grants-2006_08 |