3-Bromopropionitrile → 3-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propionitrile

HRID 80907

반응식

HRID 80907 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.Br[CH2:24][CH2:25][C:26]#[N:27]>>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][N:18]([CH2:24][CH2:25][C:26]#[N:27])[CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 170203-BromopropionitrileHCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

생성물 1

HCID 159513893-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propionitrile

실험 절차

The title compound was prepared by a similar procedure to that described in Example 55, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 3-bromopropionitrile.

출처 및 근거

ORD 기록
ord-5d1a49e8409e448394314d8374735c27
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846677B2

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