Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 80929생성일: 2026년 10월 24일
1-(Cyclopropylmethyl)piperazine → 4-(6-(4-Cyclopropylmethylpiperazin-1-yl)-pyridin-3-yl)-benzonitrile
https://huagongshe.com/ko/reaction/80929
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(Cyclopropylmethyl)piperazine | HCID 965875 | — |
| 반응물 | 4-(6-Chloro-3-pyridinyl)benzonitrile | HCID 49761821 | — |
| 생성물 | 4-(6-(4-Cyclopropylmethylpiperazin-1-yl)-pyridin-3-yl)-benzonitrile | HCID 58006667 | 43% |
반응 단계
1-Cyclopropylmethyl-piperazine (13 g, 94 mmol) was mixed with 4-(6-cloro-pyridin-3-yl)benzonitrile (5 g, 23 mmol). The mixture was heated at 140° C. for 1.5 hours. The mixture was cooled to rt and purified by column chromatography (EtOAc:petrolether=1:1) on silica gel to give 2.7 g (43%) of 4-[6-(4-cylopropylmethyl-piperazin-1-yl)-pyridin-3-yl]-benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846677B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-452190f306444fa498e29bad985dfcff |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
