Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 6-({3-chloro-5-[2-(ethylamino)ethoxy]pyridin-2-yl}oxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol | HCID 23160382 | — |
| 반응물 | Ethylamine tetrahydrofuran | HCID 66726184 | — |
| 반응물 | 2,3-Dichloro-5-(2,2-diethoxyethoxy)pyridine | HCID 86645896 | — |
| 생성물 | 6-({3-chloro-5-[2-(ethylamino)ethoxy]pyridin-2-yl}oxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine hydrochloride | HCID 42601515 | — |
반응 단계
Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol obtained in Example 1-1) and 2), and 2,3-dichloro-5-(2,2-diethoxyethoxy)pyridine and 2 M ethylamine/tetrahydrofuran solution, and in the same manner as in Example 1-3) and Example 10-2), or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (223 mg) was obtained as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846700B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-6d1b0ad4dc204ff7aac3b718c1d976c9 |
| 출처 메모 | uspto-grants-2014_09 |