Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2R)-2-(tetrahydro-2H-pyran-2-yloxy)propyl methanesulfonate → 6-[(5-{[(2R)-2-(methylamino)propyl]oxy}pyridin-2-yl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2R)-2-(tetrahydro-2H-pyran-2-yloxy)propyl methanesulfonate | HCID 59627468 | — |
| 반응물 | Methylamine tetrahydrofuran | HCID 66615946 | — |
| 반응물 | 6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol | HCID 68429877 | — |
| 생성물 | 6-[(5-{[(2R)-2-(methylamino)propyl]oxy}pyridin-2-yl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine | HCID 59508836 | — |
반응 단계
Using 6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol obtained in Example 6-3), (2R)-2-(tetrahydro-2H-pyran-2-yloxy)propyl methanesulfonate and 2 M methylamine/tetrahydrofuran solution, and in the same manner as in Example 26 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (6 mg) was obtained as a pale yellow amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846700B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-c67919467e9f4da8beae6a58ff060b04 |
| 출처 메모 | uspto-grants-2014_09 |