참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Diethyl 2-oxosuccinate,sodium salt | HCID 57351814 | — |
| 반응물 | HCID 178418806 | HCID 178418806 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | ethyl 6-oxo-1,2-dihydropyrazolo[3,4-b]pyridine-4-carboxylate | HCID 178469358 | 28.4% |
반응 단계
To a solution of 3-aminopyrazole (224 g, 2.7 mol) in water (1 L) were added a solution of diethyl oxalacetate sodium salt (567 g, 2.7 mol) in water (1.3 L) and then acetic acid in 4 portions (0.8 L). The reaction mixture was heated at 85° C. for 15 hours then cooled to room temperature and filtered. The precipitate was washed with water and then dried to afford the title compound as an orange solid (159 g, 28%). 1H NMR (250 MHz, DMSO): δ 1.35 (t, 3H), 4.36 (q, 2H), 6.69 (s, 1H), 8.16 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846712B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-e3eb65687a5b40aca63272abc8d1d7f7 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
