참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-Methyl-3-oxetanemethanol | HCID 137837 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methyl-3-[(4-methylbenzene-1-sulfonyl)methyl]oxetane | HCID 22015262 | — |
반응 단계
3-methyl-3-oxetanemethanol (100 g, 0.98 mol) was dissolved in 250 mL methylene chloride, and a 35% solution of sodium hydroxide (143.60 g, 1.08 mol)was added, and the reaction was cooled to 0° C. A solution of p-toluenesulfonyl chloride was added (186.67 g, 0.98 mol) in 375 mL methylene chloride was added over 1 hour. A white precipitate formed immediately. The reaction was stirred for 10 additional hours. 1000 mL of water was added. The dichloromethane solution layer was then removed, and dried with sodium sulfate, and the solvent was removed. Yield: 217.77 grams of 3-methyl-3-tosylmethyloxetane as white crystals, 87%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07087710B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-9c4c3610f2df4ee7bbd50d06f17076ad |
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| 출처 메모 | uspto-grants-2006_08 |
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