Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiomorpholine 1,1-dioxide → (1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 반응물 | 6-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 68441894 | — |
| 생성물 | (1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-methanone | HCID 68937601 | 100% |
반응 단계
As described for example 95, 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (103 mg, 0.3 mmol) was converted, using thiomorpholine-S,S-dioxide instead of thiomorpholine, to the title compound (133 mg, 100%) which was obtained as a white foam. MS: m/e=446.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-c642d49ac2374bc28c34669f59a2a9d0 |
| 출처 메모 | uspto-grants-2014_09 |