Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiomorpholine 1,1-dioxide → Basmisanil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 반응물 | 6-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68441898 | — |
| 생성물 | Basmisanil | HCID 57336276 | 55% |
반응 단계
As described for example 105, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (99 mg, 0.33 mmol) was converted, using thiomorpholine-S,S-dioxide instead of 2,2,2-trifluoroethylamine, to the title compound (73 mg, 55%) which was obtained as a white solid. MS: m/e=446.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-defa7aa03dd642089202778e3518a5cd |
| 출처 메모 | uspto-grants-2014_09 |