Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1,1-Trifluoro-2-propanamine → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1,1-Trifluoro-2-propanamine | HCID 3783165 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 생성물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide | HCID 68445495 | 98% |
반응 단계
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (150 mg, 0.45 mmol) was converted, using L-2,2,2-trifluoro-1-(methyl)ethylamine instead of ethanolamine, to the title compound (190 mg, 98%) which was obtained as a white solid. MS: m/e=424.0 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e220335cbfb34dccb9f3e383e9193aeb |
| 출처 메모 | uspto-grants-2014_09 |