Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester → 3-Pyridin-2-yl-isoxazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| 반응물 | (S)-2-{[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester | HCID 68444088 | — |
| 생성물 | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid | HCID 66643528 | 79% |
반응 단계
As described for example 231, 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester (9.6 g, 44 mmol), instead of (S)-2-{[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester, was converted to the title compound (6.5 g, 79%) which was obtained as an off white solid. MS: m/e=189.3 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-078174ec815040e9a7dc6dfefa375a25 |
| 출처 메모 | uspto-grants-2014_09 |