Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester → 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester | HCID 66643614 | — |
| 반응물 | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| 생성물 | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid | HCID 67157810 | 67% |
반응 단계
As described for example 358b, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d03f8ea8c7154c77a1dc9a227631559f |
| 출처 메모 | uspto-grants-2014_09 |