Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 3-Chloroisatoic anhydride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Chloro-2-[(ethoxycarbonyl)amino]benzoic acid | HCID 20325589 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-Chloroisatoic anhydride | HCID 517535 | — |
반응 단계
468 gm of N-ethoxycarbonyl-3-chloro-anthranilic acid (m.p. 111°-114° C) were refluxed in 1500 ml of dioxane with 420 ml of thionyl chloride for 3 hours while stirring. Thereafter, the reaction solution was evaporated in vacuo until crystallization started, and then cooled. The precipitate was collected by suction filtration and washed with ether. 8-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione, m.p. 225°-230° C, was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04093734 |
| 출처 데이터셋 | uspto-grants-1978_06 |
| ORD ID | ord-eabb9a499dfa4e3fa44b3f4e83befdd6 |
| 출처 메모 | uspto-grants-1978_06 |