Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 1-(trans-3-(4-Chlorophenyl)allyl)-perhydroazepin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Azepan-4-one hydrochloride | HCID 22021728 | — |
| 반응물 | p-Chlorocinnamyl chloride | HCID 53728250 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(trans-3-(4-Chlorophenyl)allyl)-perhydroazepin-4-one | HCID 68927305 | 48.3% |
반응 단계
4-Perhydroazepinone hydrochloride (2.5 g, prepared according to Synth. Commun. 1992, 1249-1258) was suspended in acetonitrile (80 ml); diisopropylethylamine (4.4 ml) and 4-chlorocinnamyl chloride (2.7 g) were successively added at room temperature and the resulting reaction mixture was stirred at room temperature for 20 hours. The solvent was removed in vacuo and the residue purified by silica gel chromatography (eluent cyclohexane:ethyl acetate 6:4) to afford 1-(trans-3-(4-chlorophenyl)allyl)-perhydroazepin-4-one (1.84 g) as a foam. MS (ES+) 264/266 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846907B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-ca98a52b02d141e9a3692979e8c3ee85 |
| 출처 메모 | uspto-grants-2014_09 |