Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Isoxazolecarbonyl chloride, 3-(2-chlorophenyl)-5-methyl- → 3-(2-Chlorophenyl)-5-methyl-n-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-isoxazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Isoxazolecarbonyl chloride, 3-(2-chlorophenyl)-5-methyl- | HCID 96590 | — |
| 반응물 | 4-[2-(2,2,2-Trifluoroethoxy)phenyl]-1-piperazinepropanamine | HCID 10567490 | — |
| 생성물 | 3-(2-Chlorophenyl)-5-methyl-n-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-isoxazole-4-carboxamide | HCID 9958830 | 67.2% |
반응 단계
The title compound was synthesised according to the procedure described in Example 8 but using 3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl chloride instead of the crude 3-(4-fluorophenyl)isoxazole-4-carbonyl chloride and Compound 12B instead of Compound 8B. Washing the reaction mixture with 2 N sodium hydroxide, followed by the usual work-up and purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3) afforded the title compound (67.2%) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06365591B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-3df818bfec0d4ac7b0dbecf936a972c2 |
| 출처 메모 | uspto-grants-2002_04 |