Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diphenyl disulfide | HCID 13436 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | PyBOP | HCID 2724699 | — |
| 반응물 | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide | HCID 76035045 | — |
반응 단계
Compound 24 was synthesized via the route as shown in Scheme 5 above (reagents and conditions: (a) Ph3P═CH—CO2CH3, CH2Cl2; (b) NaH, Ph-S—S-Ph, DMF; (c) MCPBA, CH2Cl2; (d) LiOH, MeOH, H2O; (e) (i) NH2OTHP, PyBOP, NEt3, DMF; (ii) TFA, MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846748B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bb26cdb93aed4d7085b435cf27d4bef9 |
| 출처 메모 | uspto-grants-2014_09 |