Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-methyl-2-pyrrolidone → 2-Fluoro-5-methoxybenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | 3-Chloro-4-fluoroanisole | HCID 2773585 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Fluoro-5-methoxybenzonitrile | HCID 2774546 | — |
반응 단계
A solution of 2-Chloro-1-fluoro-4-methoxy-benzene (10.4 grams, 65.0 mmole), CuCN (6.4 grams, 71.0 mmole) and N-methylpyrrolidinone (100 ml) was refluxed for 18 hours. An additional 2.3 g CuCN was added, and the mixture was refluxed for 40 hours. The mixture was poured into 300 ml ice water and stirred for 10 minutes. This was poured into 100 ml methylene chloride and the layers were separated. The mixture was washed with water, dried over MgSO4, filtered, and concentrated to a solid (2.8 g). MW 137.12; MS (m/e) 137(M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06380218B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-3975cb63a80e47fcaea38a24e043d76d |
| 출처 메모 | uspto-grants-2002_04 |