Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 4-Chloro-2-methoxybenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2,4-Dichlorobenzothiazole | HCID 77177 | — |
| 반응물 | Methanol--water (1/1) | HCID 22242641 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloro-2-methoxybenzothiazole | HCID 4141969 | 92.4% |
반응 단계
2,4-Dichlorobenzothiazole (10.21 g, 0.05 mole) and 94% sodium hydroxide (8.30 g, 0.075 mole) were added to a 50 (V/V) % water/methanol mixed solvent (150 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 9.22 g of 2-methoxy-4-chlorobenzothiazole. Yield 92.4%, purity 100%, m.p. 55°-57° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04293702 |
| 출처 데이터셋 | uspto-grants-1981_10 |
| ORD ID | ord-1378ba8683e34588b66f6a2080ac745c |
| 출처 메모 | uspto-grants-1981_10 |