참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sunitinib hydrochloride | HCID 86691060 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Sunitinib | HCID 5329102 | 78.3% |
반응 단계
Sunitinib hydrochloride (1.0 g) and H2O (60 mL) was added into a flask in r.t. and heated to 90° C., the mixture turned clear, pH of the mixture was adjusted to 8˜9 with 1N NaOH and cooled r.t. stirred over night, filtered, washed, dried in vacuo to give 0.67 g of crude sunitinib with 99.0% purity by HPLC analysis in 78.3% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846953B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ec7d05eb1cef40c8b6783229183d3fe6 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
