Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 85145생성일: 2026년 10월 23일
4-Fluoro-2-(trifluoromethyl)benzaldehyde → 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester
https://huagongshe.com/ko/reaction/85145
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Fluoro-2-(trifluoromethyl)benzaldehyde | HCID 522940 | — |
| 반응물 | ethyl 4,5-diaminonicotinate | HCID 58278930 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Nitrobenzene | HCID 7416 | — |
| 생성물 | 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester | HCID 67203080 | 39% |
반응 단계
A mixture containing ethyl 4,5-diaminonicotinate (79; 0.9 g, 5 mmol) and 4-fluoro-2-(trifluoromethyl)benzaldehyde (82; 1.0 g, 5.2 mmol) in nitrobenzene (50 mL) was stirred at 220° C. for 18 h. Upon cooling to room temperature, the reaction mixture was diluted with ether. The resulting solids were collected by filtration, washed with ether, and dried to provide 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester 83 (600 mg, 39%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846947B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-b328a1b49fd64a988b49f4986f52c821 |
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| 출처 메모 | uspto-grants-2014_09 |
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