Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-Bromo-5-(2-morpholinoethoxy)benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| 반응물 | 2-Bromo-5-hydroxybenzaldehyde | HCID 387179 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Bromo-5-(2-morpholinoethoxy)benzaldehyde | HCID 19261811 | 72% |
반응 단계
To a mixture of 2-bromo-5-hydroxybenzaldehyde (62; 3 g, 15 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (120; 5.6 g, 30 mmol) in DMF (75 mL) was added K2CO3 (10.3 g, 74.6 mmol). After reaction 2 h at 120° C. for 3 h, the reaction mixture was quenched by addition of water and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Column chromatography afforded 2-bromo-5-(2-morpholinoethoxy)benzaldehyde 121 (3.3 g, 72%) as a brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846947B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d53fcca164194a3fbffe99193f0acfc9 |
| 출처 메모 | uspto-grants-2014_09 |