Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Dimethylaminopyridine → 2-Hydroxy-5-(9z,12z,15z)-octadeca-9,12,15-trienamidobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | Methyl 5-amino-2-hydroxybenzoate | HCID 135127 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Linolenic Acid | HCID 5280934 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Hydroxy-5-(9z,12z,15z)-octadeca-9,12,15-trienamidobenzoic acid | HCID 44626053 | 80.9% |
반응 단계
To a solution of (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid (1.66 g, 5.98 mmol) and methyl 5-amino-2-hydroxybenzoate (1.0 g, 5.98 mmol) in methylene chloride (100 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.16 g, 6.0 mmol) and dimethylaminopyridine (100 mg). The mixture was stirred under N2 (14 h) and then diluted with methylene chloride (100 mL) and washed successively with 3N HCl, saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give the corresponding amide (2.0 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846972B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e5d441e51e2d47b999881497bd9efa37 |
| 출처 메모 | uspto-grants-2014_09 |