참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Nicotinamidine hydrochloride | HCID 202042 | — |
| 반응물 | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-(3-Pyridyl)-6-(4-pyridyl)pyrimidin-4-one | HCID 135409393 | 50.2% |
반응 단계
ethyl 3-(4-pyridyl)-3-oxopropionate (0.60 g), 3-amidinopyridine hydrochloride (0.54 g) and potassium carbonate (1.15 g) were added to 5 ml of ethanol, and the mixture was heated under reflux at 75° C. for 20 hours. Acetic acid was added to the reaction mixture, and the solvent was removed by distillation. The residue was added with water and then with acetic acid, and the resulting solid was separated by filtration, washed with water and ethyl acetate, and dried to obtain 0.39 g of the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07256199B1 |
|---|
| 출처 데이터셋 | uspto-grants-2007_08 |
|---|
| ORD ID | ord-80f553bfe6ea4338b734b2fe6562c22a |
|---|
| 출처 메모 | uspto-grants-2007_08 |
|---|
