Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-{4-[4-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxymethyl]-2-methyl-phenyl}-propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-(4-Iodomethyl-2-methyl-phenyl)-propionic acid methyl ester | HCID 57431974 | — |
| 반응물 | 4-Isopropyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-methanol | HCID 58765762 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{4-[4-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxymethyl]-2-methyl-phenyl}-propionic acid methyl ester | HCID 69470872 | 62.2% |
반응 단계
To a mixture of [4-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol (0.056 g, 0.18 mmol) and 3-(4-Iodomethyl-2-methyl-phenyl)-propionic acid methyl ester (0.070 g, 0.22 mol) in DMF (1 mL) is added sodium hydride (60% dispersion, 0.016 g, 0.67 mmol). After 3.5 h, water is added, and the mixture is extracted with EtOAc. The organics are dried with MgSO4 and concentrated. The crude material is purified by flash chromatography to yield the title compound (55 mg, 60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07259175B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-4aba11daedae42cda1a16f8c20d5eaa3 |
| 출처 메모 | uspto-grants-2007_08 |