Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1S)-1-(4-Nitrophenyl)ethan-1-amine → N-(4-Carbamimidoyl-phenyl)-N'-[1-(4-nitro-phenyl)-ethyl]-2-phenyl-malonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1S)-1-(4-Nitrophenyl)ethan-1-amine | HCID 1268055 | — |
| 반응물 | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| 반응물 | n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt | HCID 23700157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(4-Carbamimidoyl-phenyl)-N'-[1-(4-nitro-phenyl)-ethyl]-2-phenyl-malonamide | HCID 15907897 | — |
반응 단계
75 mg (0.235 mmol) of the sodium salt from example 2 were dissolved in 2.5 ml DMF. 85 mg (0.265 mmol) TOTU in 2.5 ml DMF were added and stirred for 30 min at rt. Then 34 μl (0.265 mmol) NEM and 53.7 mg (0.265 mmol) of (S)-1-(4-nitrophenyl)-ethylamine in 0.5 ml of DMF was added and the mixture stirred at rt overnight. After filtration, the filtrate was evaporated to dryness and purified by prep. RP-HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07153876B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-f65f81e630ba4ccd97685b5e2d118511 |
| 출처 메모 | uspto-grants-2006_12 |