참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Venlafaxine | HCID 5656 | — |
| 반응물 | 1-Dodecanethiol | HCID 8195 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 생성물 | Desvenlafaxine | HCID 125017 | — |
반응 단계
Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred for 2 hours at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07154001B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-014df8edd2784c42bdd24c0f8e68eb7e |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
