Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate → tert-butyl N-(azetidin-3-ylmethyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate | HCID 22257620 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-butyl N-(azetidin-3-ylmethyl)carbamate | HCID 15346872 | 67.1% |
반응 단계
3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723444 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-ecbc4c566e744d9b960cfaf350b242df |
| 출처 메모 | uspto-grants-1998_03 |